| Product description | The recombinant fusion protein contains immunodominant regions of OspC (Outer surface protein C) antigen of different Borrelia species (Borrelia burgdorferi, Borrelia afzelii, Borrelia garinii) |
| Purification methods | Purified by affinity chromatography |
| Buffer composition | 50mM Tris, 5mM Glutathione, pH8.0 |
| Preservative | None |
| Storage | Frozen at -70 ˚C, avoid repeated freeze-thaw cycles |
Vitrotest is a manufacturer of recombinant mosaic protein, which is an analogue of the OspC antigen produced in the E.coli expression system. Another recombinant mosaic protein, VLsE, produced in the E. coli expression system is also available. Both recombinant analogues contain epitopes that are recognized by specific antibodies in serum samples from the patients. These Borrelia burgdorferi proteins are the main diagnostic markers of infection.
- OspC is a highly immunogenic protein that interacts with components of the host immune system.
- VlsE is an envelope protein that evades the immune response due to its variable domains. It is known, however, that epitopes are found in both variable and conserved regions.
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Product description The recombinant fusion protein contains immunodominant regions of VlsE (Lyme disease variable surface antigen E) antigen of different Borrelia species (Borrelia burgdorferi, Borrelia afzelii, Borrelia garinii) Purification methods Purified by affinity chromatography Buffer composition 50mM Tris, 5mM Glutathione, 1mM bME, pH8.0 Preservative None Storage Frozen at -70 ˚C, avoid repeated freeze-thaw cycles